![]() Alpha-hydroxy-amphetamine undergoes deamination to form phenylacetone, which ultimately forms benzoic acid and its glucuronide and the glycine conjugate hippuric acid. Norephedrine and 4-hydroxy-amphetamine are both active and each is subsequently oxidized to form 4-hydroxy-norephedrine. Very common (10% or more): Headache (up to 26%)Ĭommon (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)įrequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette's syndrome DermatologicĬommon (1% to 10%): Photosensitivity reaction, sweatingįrequency not reported: Urticaria, rash, alopecia, serious skin rashes (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis) EndocrineĬommon (1% to 10%): Decreased libido, dysmenorrhea, impotenceįrequency not reported: Frequent or prolonged erections GenitourinaryĬommon (1% to 10%): Urinary tract infection OtherĬommon (1% to 10%): Fever, infection, accidental injury, asthenia/ fatigue, tooth disorder (e.g., teeth clenching, tooth infection)įrequency not reported: Sudden death, bruxism RespiratoryĬommon (1% to 10%): Dyspnea Hypersensitivityįrequency not reported: Hypersensitivity reactions (e.g.Amphetamine is reported to be oxidized at the 4 position of the benzene ring to form 4- hydroxyamphetamine, or on the side chain α or β carbons to form alpha-hydroxy-amphetamine or norephedrine, respectively. Very common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)Ĭommon (1% to 10%): Emotional lability, agitation, anxietyįrequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania Nervous system Very common (10% or more): Transient blood pressure elevations (up to 35%)Ĭommon (1% to 10%): Tachycardia, palpitationįrequency not reported: Cardiomyopathy, myocardial infarction, Raynaud's phenomenon Psychiatric Very common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)Ĭommon (1% to 10%): Nausea, vomiting, diarrhea, dyspepsiaįrequency not reported: Unpleasant taste, constipation, other GI disturbances Cardiovascular Very common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)įrequency not reported: Anorexia Gastrointestinal twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legsĪpplies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.loss in sexual ability, desire, drive, or performance.decreased interest in sexual intercourse.Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of amphetamine / dextroamphetamine may occur that usually do not need medical attention. sores, ulcers, or white spots in the mouth or on the lips.seeing, hearing, or feeling things that are not there.red skin lesions, often with a purple center.pain or discomfort in the arms, jaw, back, or neck.muscle spasm or jerking of the arms and legs.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.inability to move the arms, legs, or facial muscles.Blistering, peeling, or loosening of the skin.general feeling of discomfort or illness. ![]() fast, pounding, or irregular heartbeat or pulse.difficult, burning, or painful urination.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking amphetamine / dextroamphetamine: More common Serious side effectsĪlong with its needed effects, amphetamine / dextroamphetamine may cause some unwanted effects. Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions.ĬNS stimulants, including dextroamphetamine/ amphetamine extended-release capsules, other amphetamine-containing products, and methylphenidate, have a high potential for abuse and dependence. Amphetamines have a high potential for abuse and administration for prolonged periods of time may lead to drug dependence. ![]()
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